Regulation of metastatic action through CXCR4 and HPV16 E6/7 in cervical carcinogenesis
نویسندگان
چکیده
Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Taiwan Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Taiwan Division of Traumatology, Department of Surgery, Chi Mei Medical Center, Taiwan Department of Cardiology, Tainan Municipal Hospital, Taiwan Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, Taiwan Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Taiwan
منابع مشابه
Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells
Development of cervical squamous cell carcinoma requires increased expression of the major high-risk human-papillomavirus (HPV) oncogenes E6 and E7 in basal cervical epithelial cells. We used a systems biology approach to identify host transcriptional networks in such cells and study the concentration-dependent changes produced by HPV16-E6 and -E7 oncoproteins. We investigated sample sets deriv...
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High-risk human papillomaviruses, such as HPV16, cause cervical cancers, other anogenital cancers, and a subset of head and neck cancers. E6 and E7, two viral oncogenes expressed in these cancers, encode multifunctional proteins best known for their ability to bind and inactivate the tumor suppressors p53 and pRb, respectively. In skin carcinogenesis experiments using E6 transgenic (K14E6(WT)) ...
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